34 Successive Bouts of Exercise Influences the Inflammatory Cytokine Response in Thoroughbred Horses Regardless of Recovery Aid Supplementation

Abstract In equine sports, the rate of recovery after an exhaustive exercise session greatly affects ability animal to perform subsequently, especially if next occurs quickly. Carnitine participates in fatty acid delivery mitochondria and may facilitate muscle post-exercise. The objective study was determine effects a commercially available carnitine supplement (Renew, Platinum Performance, Buellton, CA) on adult Thoroughbred horses (16 geldings, 2 mares, 6.69 ± 0.49 years, 524.81 10.07 kg, 5.66 0.12 BCS) successive bouts exercise. All participated moderate workload conditioning program for 6-weeks before testing. Horses received ration applesauce (30 mL, CON, n = 8) or containing 19.6 g product AID, 1 h performing incremental standardized test (iSET) exhaustion (day 1). Heart (HR) gait biomechanics were recorded throughout duration iSET. Blood collected at 0, 10 min, 1, 4 6 relative measurement lactate interleukin (IL) 1b, 8 mRNA content. IL8 IL10 AID administered again post-iSET collection blood sample. rested 24 repeating iSET 3) with performance data sample collection. did not affect time maximum HR, reach V200 total gallop during day 3. HR decline post slower (P < 0.05) all 3 compared 1. concentration affected by day. right front limb posterior fetlock angle full stance phase increased speed both CON supplemented receiving demonstrated increase this measure while no significant differences > detected CON. Administration whole IL1b, content Consolidation demonstrates expression IL1b post-exercise that absent Expression altered over days. Results experiment demonstrate inflammatory response exhaustion. Although IL gene expression, it promote retention flexion joint suggesting products from strenuous